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David W. Meinke |  |
| Oklahoma State University | ||
 Regents Professor, Department of Botany |
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| Address:
104 Life Sciences
East, OSU, Stillwater, OK 74078
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| Phone:
405-744-6549
Fax: 405-744-7074
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| Email:
david.meinke@okstate.edu |
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| URL:
http://mutant.lse.okstate.edu http://www.seedgenes.org |
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| Ph.D.,
Biology, 1979, Yale University |
Lab Photo | |
| Postdoctoral: Plant
Molecular Biology, 1979-82, Washington University
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| Research
Emphasis: Molecular
genetics of seed development in Arabidopsis; Plant functional genomics |
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| Related
Activities: Program
Director, NSF Plant Genome Program (FY98) Curator of Arabidopsis Genes with Mutant Phenotypes |
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| Research
Description: The purpose of my research program over the past 25 years has been to explore the genetic control of seed development in plants through the isolation and characterization of embryo-defective mutants of Arabidopsis thaliana. I have long promoted the use of Arabidopsis as a model system for plant biology and have been fortunate to serve in a number of leadership capacities on behalf of the Arabidopsis community. My current research involves two main projects: (1) a focused analysis of a small collection of titan mutants with fascinating defects in chromosome mechanics and cytoskeletal organization; and (2) a large-scale genomic analysis of several hundred EMB genes with essential functions during seed development. The second project (www.seedgenes.org) is supported by the NSF 2010 Program and involves a collaboration with Syngenta (Research Triangle Park, NC) and Virginia Tech University (Blacksburg, VA). I have also become interested in Medicago research, in part through my interactions with the Noble Foundation. My long-term goal is to identify every Arabidopsis gene with a knockout seed phenotype, utilize this information to understand the molecular basis of phenotypic diversity during seed development, and establish a framework to help define the minimal gene set required to make a functional plant. |
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| Recent
Publications: Muralla R, Sweeney C, Stepansky A, Leustek T, Meinke D (2007) Genetic dissection of histidine biosynthesis in Arabidopsis. Plant Physiol. 144:890-903. Berg M, Rogers R, Muralla R, Meinke D (2005) Requirement of aminoacyl-tRNA synthetases for gametogenesis and embryo development in Arabidopsis. Plant J 44: 866-878. Meinke DW, Meinke LK, Showalter TC, Schissel AM, Mueller LA, Tzafrir I (2003) A sequence-based map of Arabidopsis genes with mutant phenotypes. Plant Physiol 131: 409-418. Tzafrir
I, Dickerman A, Brazhnik O, Nguyen Q, McElver J, Frye C, Patton
D, Meinke D (2003)
The Arabidopsis SeedGenes Project. Nucleic Acids Res
31: 90-93. |
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| Selected
Additional Publications: Golden TA, Schauer SE, Lang JD, Pien S, Mushegian AR, Grossniklaus U, Meinke DW, Ray A (2002) SHORT INTEGUMENTS/SUSPENSOR1/CARPEL FACTORY, a dicer homolog, is a maternal effect gene required for embryo development in Arabidopsis. Plant Physiol 130: 808-822. McElver J, Tzafrir, I, Aux, G, Rogers R, Ashby C, Smith K, Thomas C, Schetter A, Zhou Q, Cushman MA, Tossberg J, Nickle T, Levin J, Law M, Meinke D, Patton D (2001) Insertional mutagenesis of genes required for seed development in Arabidopsis thaliana. Genetics 159: 1751-1763. Lukowitz W,
Nickle TC, Meinke DW, Last RL, Conklin PL, Somerville C (2001) Arabidopsis
cyt1 mutants are deficient in a mannose-1-phosphate
guanosyltransferase and point to a requirement of N-linked glycosylation
for cellulose
biosynthesis. Proc Natl Acad Sci USA 98: 2262-2267. |
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